Date: Location: Welandersalen, B2, plan 0.
Recent Indian Journal of Tuberculosis Articles
Karolinska University Hospital, Solna. Time: Abstract Tuberculosis TB is the single deadliest infectious disease in the world and around one fourth of the global population is estimated to be latently infected with Mycobacterium tuberculosis Mtb. This thesis aims to contribute by identifying novel biomarkers to distinguish the different stages of infection, from latency to active disease and thereby identify individuals in need of treatment. However, neither assay can distinguish a previously healed from an active TB.
Nor can they distinguish individuals with a recent Mtb infection with increased risk of incipient TB, from a remote and well-controlled infection. Thus, the positive predictive values for active TB are very low. There is a need for more sensitive biomarkers to identify individuals with increased risk of progression to active disease, in order to better control and prevent transmission of TB. A mathematical model was developed in the third paper using clinical and epidemiological data to estimate the probabilities of recent and remote latent TB.
Other Mtb antigens Rec85a, Rec85b and Rv were also sensitive markers of recent infection, but did not distinguish recent from remote infection. The findings from our studies indicate that positive predictive values for incipient TB in Mtb assays can be improved and aid clinicians in targeting those in need of treatment to prevent disease and further transmission of active TB, as well as avoid unnecessary costs and adverse events.
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Phd thesis tuberculosis
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